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As part of a company providing support to bring gene-signature based diagnostics to the market, I have full exposure to the scientific discovery, validation process and influence of multiple stakeholders in the diagnostic field. Not only are some diseases hard to diagnose without checking on a molecular level, we can also give a better prognosis or choose the right treatment for your type of condition. And who would not want to know whether they inherited some “difficult genes” from their parents? What else do your molecules tell about you and what could anyone else possibly do with that information? I’d like to bring some awareness to the audience about the potential of sequencing-based technology in health and disease and the issues it might bring along, which are of bigger concern and much closer to reality than “choosing the ideal genes for your baby”. NB: I am here as a critical individual and (computational) biologist, not as an employee.